Computational Systems Biology: Modeling and Simulation of Biological Systems

(Same as Bioengineering CM186, Computer Science CM186, and Ecology and Evolutionary Biology M178.) Dynamic biosystem modeling and computer simulation methods for studying biological/biomedical processes and systems at multiple levels of organization. Intermediate linear and nonlinear control system, multicompartmental, epidemiological, pharmacokinetic, and other biomodeling methods applied to life sciences problems at molecular, cellular, organ, and population levels. Both theory- and data-driven modeling, with focus on translating biomodeling goals and data into dynamical mathematical models, and implementing them for simulation, quantification, and analysis. Numerical simulation, optimization, and parameter identifiability and search algorithms, with model discrimination and analysis and software exercises in PC laboratory assignments.

Letter grading.